An article from MIT News, it's a long read but it's worth it, excerpt :
" In the fall of 1917, a new strain of influenza swirled around the globe. At first, it resembled a typical flu epidemic: Most deaths occurred among the elderly, while younger people recovered quickly. However, in the summer of 1918, a deadlier version of the same virus began spreading, with disastrous consequence. In total, the pandemic killed at least 50 million people — about 3 percent of the world’s population at the time.
That two-wave pattern is typical of pandemic flu viruses, which is why many scientists worry that the 2009 H1N1 (“swine”) flu virus might evolve into a deadlier form.
H1N1, first reported in March 2009 in Mexico, contains a mix of human, swine and avian flu genes, which prompted fears that it could prove deadlier than typical seasonal flu viruses. However, the death toll was much lower than initially feared, in large part because the virus turned out to be relatively inefficient at spreading from person to person.
In a new study from MIT, researchers have identified a single mutation in the H1N1 genetic makeup that would allow it to be much more easily transmitted between people. The finding, reported in the March 2 edition of the journal Public Library of Science (PLoS) One, should give the World Health Organization, which tracks influenza evolution, something to watch out for, says Ram Sasisekharan, senior author of the paper."
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